UTILITY OF 3-HYDROXY-2-(2-METHOXYPHENYL)-4H-CHROMEN-4-ONE AS ANTIOXIDANT FEED SUPPLEMENT ON MILK PRODUCTION AND GROWTH RATE IN GOATS

SOLIMAN, MANAR R.A.; SALEM, MARWA S.; ABOU-AMMOU, FATEN; MADKOUR, HASSAN M.F.

doi:10.21608/avmj.2025.377595.1669

UTILITY OF 3-HYDROXY-2-(2-METHOXYPHENYL)-4H-CHROMEN-4-ONE AS ANTIOXIDANT FEED SUPPLEMENT ON MILK PRODUCTION AND GROWTH RATE IN GOATS

Document Type : Research article

Authors

¹ Sheep and Goat Research Department, Animal Production Research Institute, Agricultural Research Centre, Dokki, Giza, Egypt.

² Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.

10.21608/avmj.2025.377595.1669

Abstract

The study aimed to investigate the effect of 3-Hydroxy-2-(2-methoxyphenyl)-4H-chromen-4-one / (2'-methoxy flavonol, 4) on oxidative stresses, milk production and growth rate of Zaraibi goats, compared to the standard antioxidant vitamin C. The 2'-methoxy flavonol (4) has been synthesized throughout the oxidative cyclization of 1-(2'-Hydroxyphenyl)-3-(2-methoxyphenyl) prop-2-en-1-one 3, the structure of 3 & 4 have been characterized by melting points (mp), and the spectroscopic tools. The total antioxidant capacity (TAC) of compounds 3 & 4 has been measured using the phosphomolybdenum assay.
Twenty-four pregnant Zaraibi goats were randomly distributed into three groups. The control group (CG) received the basal diet (BD), the flavonoid group (FG) received the BD plus (60 mg/kg body weight/d) of 4, and the ascorbic acid group (AAG) received the BD plus (60 mg/kg body weight/d) of vitamin C.
The results indicated that the two synthesized compounds 3 & 4 have good antioxidant capacity. The daily milk yield (DMY), milk fat content, and the average daily weight gain (DWG) of goats' kids of FG increased significantly compared to the CG and AAG groups. The results also indicated that all blood parameters were within the normal range. In conclusion, the use of the 2'-methoxy flavonol 4 as antioxidant feed supplement in the diet of pregnant Zaraibi goats can reduce the oxidative stresses, increase the daily milk yield, the milk fat percentage, and increase the average daily weight gain of goats' kids without any adverse effect on the nutritional and physiological status of animals.

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