AMELIORATIVE ROLE OF FOENICULUM VULGARE SEED OIL ON PHYSIOLOGICAL DISORDERS ACCOMPANIED PHENYLHYDRAZINE-INDUCED TOXICITY IN MALE ALBINO RATS

Document Type : Research article

Authors

Department of Zoology, Faculty of Science, Benha University, Benha, Egypt.

Abstract

Phenylhydrazine (PhH) is an aromatic organic compound with broad applications in various fields, including chemistry, pharmaceuticals, and agriculture. Additionally, it serves as a model for studying toxicity in biological and medical research. This study aims to explore the potential of Foeniculum vulgare seed oil (FSO) as a natural remedy to mitigate the harmful effects of PHZ toxicity. The experiment involved five groups of male rats: the control group was administered distilled water for 14 days; the FSO group received a daily oral dose of 0.5 ml/kg FSO for 14 days; the PhH group was intraperitoneally injected with 60 mg/kg PhH over three consecutive days; the FSO + PhH group was treated with FSO orally for 11 days before being injected with PhH; and the PhH + FSO group was given PhH injections for three days, followed by daily oral doses of FSO for 11 days. Blood samples were taken from the rats on day 15 to analyze haematological and biochemical levels. Rats treated with PhH exhibited elevated levels of malondialdehyde (MDA), leukocytes, liver panel, kidney panel, and erythropoietin, while catalase (CAT), superoxide dismutase (SOD), erythrocytes, haematocrit (Hct), haemoglobin (Hb), and thrombocytes levels were reduced relative to the control group. Administration of FSO to PhH-treated rats improved oxidative stress, haematological parameters, liver panel, kidney panel, and erythropoietin levels. In summary, FSO was effective in reducing the disturbances in oxidative stress, haematological parameters, liver and kidney panels, and erythropoietin levels induced by PhH treatment in rats.

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Assiut Veterinary Medical Journal
Volume 71, Issue 187
October 2025
Pages 191-200

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