INULINA MITIGATES ACYCLOVIR-INDUCED HEPATOTOXICITY IN ADULT FEMALE RATS

Document Type : Research article

Authors

1 Department of Biology, College of Education for Pure Sciences, University of Mosul, Mosul, Iraq. ORCID: 0000-0001-8901-6444

2 Department of Optical Techniques, College of Health and Medical Techniques, Alnoor University, Mosul, Iraq. ORCID:0000-0001-8446-1725

3 Department of Pharmacy, College of Pharmacy, Al-Noor University, Mosul, Iraq. ORCID: 0000-0001-7596-2106

Abstract

Inulina is considered a natural compound that has been used as food additive for its medicinal benefits. So several physiological, biochemical, and histological changes in adult female Wistar rats were examined to analyze the possible protective role of inulina against acyclovir-induced liver damage. Twenty-four adults female Wistar rats were selected randomly and divided into four equal groups of 6 rats/group. The first group the control was given water. The second group (A1) was given 500 mg/kg body weight of inulina taken through mouth. The third set (A2) was given acyclovir (450 mg/kg body weight) in drinking water. In the fourth group (A3), acyclovir (450 mg/kg body weight) was given, and inulina (500 mg/kg body weight) was used to alleviate symptoms. All these treatments were given daily. Samples of blood were taken at days (0, 24, and 46) of the experiment, to perform liver and kidney function tests, also liver slices were examined for histological analysis. The results indicated that the activity of liver enzymes was significantly increased in rats administered acyclovir (A2). In addition, changes in the liver tissue. The protective function of inulina was very clear in group (A1) and (A3). We conclude that inulina, as an antioxidant, can protect adult female livers from hepatic damage induced by acyclovir.

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