Document Type : Research article
Authors
1
Department of Biology, College of Sciences, University of Mosul, Mosul, Iraq.
2
Department of Biology, College of Science, Mosul University, Mosul, Iraq
Abstract
The study aimed to evaluate the effects of some nutritional supplements (NSs) and testosterone hormone, commonly used in sports training centers, on liver function and creatine kinase (CK) enzyme activity. The experiment was conducted on 80 male white rats, divided into eight groups with 10 rats in each group. The groups included: a control group, a group of rats exercised using a treadmill, a group treated with NS, a group injected with a testosterone blend, a group dosed with NS and injected with a testosterone blend, a group treated with NS and exercised, a group injected with a testosterone blend and exercised, and a group treated with NS, injected with a testosterone blend and exercised. The results showed a significant increase in the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine kinase (CK) enzymes in the group treated with NS and testosterone blend compared to the other groups. Histological examinations of the liver revealed severe hepatocyte necrosis, disappearance of some nuclei, apoptosis in certain cells, fatty changes (steatosis) with loss of cellular boundaries, focal infiltration of Kupffer cells, and severe sinusoidal congestion in rats treated with NS and testosterone blend. In contrast, the other groups exhibited normal hepatic cells. In conclusion, treatment with NS and testosterone blend negatively impacts liver enzyme activity and CK levels, in addition to causing pathological changes in liver tissue.
Keywords
Main Subjects
)
View on SCiNiTO