EFFECT OF NANO-SELENIUM PARTICLES ON REPAIRING DISTAL PART RADIAL BONE FRACTURE IN DOGS: RADIOLOGICAL EVALUATION

Document Type : Research article

Authors

1 Department of Medical Laboratory Techniques, Al-Huwayjah Technical Institute, Northern Technical University, Iraq

2 Department of Surgery and Theriogenology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

Abstract

Nanotechnology science has significantly changed the field of drug development and alternative therapies because of its great biocompatibility, low toxicity, and antioxidative properties. Nano-selenium is a promising drug delivery vehicle for antioxidant or anti-inflammatory effects, so the objective of the current study is to evaluate the effect of nano-selenium particles on distal transverse radial fracture. Twenty-four adult canine’s male which were clinically healthy, weighing (25±0.5) kg and 2±0.5 years old, were used. Dogs were randomly divided into two equal groups. In the first (control) group, a distal part transverse fracture in the radius bone was done and left without adding any material, then reduction and fixation were made. In the second (nano selenium) group, a transverse fracture was made, then treated by adding selenium nanoparticles suspension at the fracture line, then reduction and fixation were done, animals were then monitored clinically and radiographically. Clinically, all experimental dogs showed smooth healing without any complications, but lameness in the nano selenium group subsided more quickly than in the control group. Radiographical results of the nano-selenium group showed good periosteal reaction and callus formation from the second week. Moreover, the fracture line disappeared and returned to normal bone shape in the eighth week. But in the control group, this finding was less clear than in the nano selenium group. The use of selenium nanoparticles accelerated the healing process of distal radial transverse fractures.

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