BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES ASSOCIATED WITH RECORDED CASES OF CHRONIC PANCREATITIS AND PANCREATIC FAT NECROSIS IN CATTLE

ABDELATTY, SHIMAA ABDULLAH; HASSANEIN, KHALED M.A.; ABOU EL-ELLA, GHADA AHMED; ABD ELLAH, MAHMOUD RUSHDI

doi:10.21608/avmj.2025.364163.1604

BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES ASSOCIATED WITH RECORDED CASES OF CHRONIC PANCREATITIS AND PANCREATIC FAT NECROSIS IN CATTLE

Document Type : Research article

Authors

¹ Department of Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt

² Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt

10.21608/avmj.2025.364163.1604

Abstract

This study aimed to investigate the biochemical and pathological changes in chronic pancreatitis and pancreatic fat necrosis of cattle. The study included 32 cattle of different ages and sexes selected from animals slaughtered at El-Minia governorate slaughterhouses. Gross and histopathological examinations were used for the identification of pancreatic diseases. Among the 32 animals, 13 cases were identified as chronic pancreatitis, nine cases were diagnosed as pancreatic fat necrosis, and 10 cattle were clinically healthy and had no postmortem lesions represented the control group. Two blood samples were collected from each animal before slaughtering. Serum samples were used to estimate insulin, lipase, amylase, aspartate aminotransferase, gamma-glutamyl transferase (γGT), total proteins, albumin, globulin, creatinine, urea, and lipid profile. A plasma sample was used to estimate blood glucose levels. Pancreatic tissue specimens were subjected to histopathological examination. In chronic pancreatitis, there was a significant increase in serum amylase activity, creatinine level, and urea levels, while in pancreatic fat necrosis, there were significant increases in serum lipase activity, an increase in serum creatinine level, an increase in serum urea level and a decrease in serum γGT activity. It could be concluded that chronic pancreatitis and fat necrosis in cattle do not affect blood glucose and insulin levels. Serum urea and creatinine levels increase in both conditions. Serum amylase activity increases in chronic pancreatitis. However, serum lipase activity elevates in fat necrosis.

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