INVESTIGATING THE EFFECTS OF CHASTEBERRY AND GREEN TEA EXTRACT ON POLYCYSTIC OVARIAN SYNDROME RAT MODELS

Document Type : Research article

Authors

1 Department of Clinical Laboratory Science, University of Basrah, College of Pharmacy, Iraq.

2 Department of Animal Production Techniques, Technical Agricultural College of Mosul, Northern Technical University, Iraq

Abstract

Polycystic ovarian syndrome is a gynaecological disorder associated with diverse health issues affecting numerous body systems. Therefore, this study was conducted to investigate the possible effect of chasteberry and green tea extract in treating polycystic ovary disorder. Twenty-four female rats were divided into four groups. Group I control was treated with distilled water. Group II positive control (polycystic ovary) treated with 1mg/kg letrozole orally for 4 weeks. Group III was treated with 1 mg/kg of letrozole administered orally, along with 750 mg/kg of chasteberry extract, for 4 weeks. Group IV was treated with 1 mg/kg of letrozole orally, combined with 250 mg/kg of green tea extract, for 4 weeks. At the end of the study, all animals were sacrificed for hormonal analysis and histopathological evaluation. Hormonal pictures of both extracts show a significant (P<0.05) increase in serum follicle-stimulating hormone along with a significant (P<0.05) reduction in serum prolactin hormone and luteinizing hormone, compared to the positive control group. Microscopically, there is a reduction in size and number of ovarian cystic follicles and restoration of normal ovary structure, presence of Graafian follicles with their corpora lutea and restoration of ovulation. These findings support the therapeutic potential of chasteberry extract and green tea extract in controlling and managing induced cystic ovaries in rat models.

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