Document Type : Research article
Authors
1
Biochemistry, Nutritional Deficiency Diseases and Toxicology Unit, Kafrelsheikh Provincial Lab, Animal Health Research Institute, Agricultural Research Center (ARC), Giza, Egypt.
2
Poultry Diseases Unit, Kafrelsheikh Provincial Lab, Animal Health Research Institute, Agricultural Research Center (ARC), Giza, Egypt.
3
Bacteriology Unit, Kafrelsheikh Provincial Lab, Animal Health Research Institute, Agricultural Research Center (ARC), Giza, Egypt.
4
Faculty of Veterinary Medicine, Kafrelsheikh University, Pathology Department.
Abstract
The use of antibiotics in the poultry industry has been restricted. As a result, the phytogenic feed additives have been increasely utilized to serve this purpose, as well as for other benefits. This study aimed to investigate the effects of cinnamon nanoparticles (CNPs) on rabbit growth performance, immunity, serum biochemistry, blood hematology, cell histology, and protection against Escherichia coli O25.Therefore, sixty healthy weaned white New Zealand rabbits (35 days old) were separated into six equal groups. The rabbits were acquired from a private farm in Kafrelsheikh Governorate and acclimated for two weeks before the starting of the experiment. The rabbits groups were divided according to CNPs supplementation with or without antibiotic and experimental infection. According to our findings, the rabbits that received CNPs exhibited improved growth performance, P.M. lesions, bacterial re-isolation outcomes, and clinical symptoms. The hepatic and reno-protective effects of CNPs may be supported by decreases in the activities of serum ALT and AST and increases in the level of total protein and albumin, counts of total white blood cell and lymphocyte, and activities of antioxidant enzyme (SOD and CAT). The histopathological analysis showed that the positive control group had apparent pathological changes, such as interstitial nephritis, hepatic coagulative necrosis, and interstitial pneumonia with mononuclear cell infiltration. However, the superior effect was observed in the CNPs and streptomycin-treated group with milder to moderately altered tissue conditions. Thus, under current experimental conditions, dietary CNPs improved growth performance, antioxidant activity, and protection against experimental infection without pathological lesions.
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