EVALUATION OF THE ANTI-ADHESIVE EFFICACY OF GELATIN SPONGE AND ALGINATE SPONGE IN THE PREVENTION OF POST-SURGICAL INTRA-ABDOMINAL ADHESIONS

SADEK, AHMED ABDELRAHIEM; EID, HAJAR; RADAD, KHALED; AHMED, AHMED FATHY

doi:10.21608/avmj.2024.322977.1406

EVALUATION OF THE ANTI-ADHESIVE EFFICACY OF GELATIN SPONGE AND ALGINATE SPONGE IN THE PREVENTION OF POST-SURGICAL INTRA-ABDOMINAL ADHESIONS

Document Type : Research article

Authors

¹ Department of Surgery, Anesthesiology, and Radiology, College of Veterinary Medicine, Assiut University, Assiut 71526, Egypt.

² Veterinarian and Post-Graduate Student, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt.

³ Department of Pathology and Clinical Pathology, College of Veterinary Medicine, Assiut University, Assiut 71526, Egypt.

10.21608/avmj.2024.322977.1406

Abstract

The occurrence of intra-abdominal adhesions after abdominal surgical interventions is considered an important issue in veterinary clinics. Although several adhesion-reducing agents were evoked to overcome the formation of such intra-abdominal adhesions, their effectiveness was still unsatisfactory. Hence, the present study assessed and compared the antiadhesive capability of gelatine and alginate sponges to minimize or prevent the formation of post-surgical intra-abdominal adhesions in a rabbit model. The cecal abrasion model was induced in animals and left untreated as control positive or treated with either intra-abdominal application of gelatine sponge (GS) or alginate sponge (AS). Clinical observation, gross appearance and histological evaluations were performed after 2 weeks of surgery. Grossly, the gelatine sponge enhanced the formation of intra-abdominal adhesions compared to the alginate sponge and control positive groups. Furthermore, both GS-treated and sham groups revealed no fibrosis on histological outcomes. The AS-treated group induced an extensive reaction with the formation of a marked degree of fibrosis and inflammatory cell infiltration. It was concluded that a gelatine sponge possesses the potential to prevent adhesions that could be formed intra-abdominally after abdominal surgery. An alginate sponge stimulates the formation of these adhesions.

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