EVALUATION OF NANO AND CONVENTIONAL FORMS OF LAMBDA-CYHALOTHRIN TOXICITY IN RATS

Document Type : Research article

Authors

1 Animal Health Research Institute, Egypt.

2 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.

3 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.

4 Professor of Pathology and Clinical pathology Faculty of Veterinary Medicine, Assuit University

Abstract

Nano-pesticides have been created to substitute traditional pesticides and enhance agricultural techniques. The utilization of nano-pesticides poses a considerable obstacle due to the insufficiency of information regarding their prospective ecotoxicity, especially animal, human, and other non-target organism toxicity. This study was conducted to evaluate the toxicity of the nano-emulsion Lambda-cyhalothrin compared with the conventional one, depending on investigating the organ weight index and histopathological examination of vital organs in treated rats. There was no significant difference between the effects of conventional and nanoform of Lambda cyhalothrin on body weight index. Still, there was a significant elevation in the relative weight of the liver and kidney in conventional Lambda cyhalothrin and nano-treated rats. Histopathological results of conventional Lambda cyhalothrin-treated rats indicated marked vacuolar degenerated hepatocytes, hypercellularity in the glomeruli, vascular hemorrhage in the cerebral cortex, and vacuolization of Leydig cells. While nano Lambda cyhalothrin-treated rats showed hepatocytes with dilated and congested blood vessels and Kupffer cell activation, necrosis of some renal tubular epithelium, and intratubular mononuclear cell infiltration. The cerebral cortex showed some pyknotic Purkinje cells, and spermatogenic cells were decreased.

Keywords

Main Subjects

Assiut Veterinary Medical Journal
Volume 70, Issue 183
October 2024
Pages 685-696

Files

Share

How to cite

Statistics