Document Type : Research article
Authors
1
B.V.Sc., Assiut University, Assiut, Egypt
2
Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt,
3
Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University,
4
Department of Physics, Faculty of Science, Assuit University, Assiut, Egypt
5
Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
Abstract
This study aimed to evaluate the healing of wounds dressed with Zn-MoF in dogs. The study was conducted on fifteen clinically healthy mongrel dogs. Each dog has bilateral cutaneous excisional wounds (2 × 2 cm2). Right-side wounds were dressed with Zn-MOF dressing (treated wounds) under the effect of 1 mg/kg of xylazine HCL 2% and 10 mg/kg of ketamine HCL 5% , administered in one syringe intramuscularly (IM), while left-side wounds were dressed with normal saline (control group). Wounds were undergone to histopathological evaluation 7-, 15-, and 21-days post-wound induction (5 dogs each interval). Zn-MOF positively enhanced the re-epithelization of the wound area promoting the epidermal hyperplasia resulting in reduction of the wound size and epithelial gap that was completely closed and restored on day 21 post-wound induction. The control wounds were at a slower healing rate with time leaving epithelial gaps and did not completely close day 21 post-wound induction. Zn-MOF treated wounds’ dermis was pervaded with the inflammatory cells on day 7 post-wound induction that gradually reduced by time and replaced by fibroblasts 14- and 21-days post-wound induction. The dermis of control wounds was severely infiltrated with a larger number of inflammatory cells and excessive hemorrhage throughout the study. Zn-MOF treated wounds had an augment in the number and size of newly formed blood vessels in comparison to the control ones, reaching their highest point on day 14- and declining on day 21 post-wound induction. Collagen deposition increased obviously 21 days post-wounding in Zn-MOF treated wounds. Zn-MOF accelerated and enhanced the wound healing process and abundant granulation tissue formation in dogs.
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