TRIALS FOR PRODUCTION OF ALUMINUIUM HYDROXIDE GEL AND OILY ADJUVANT INACTIVATED NEWCASTLE DISEASE VACCINES, IN COMPARISON WITH COMMERCIAL IMPORTED OILY VACCINE

Document Type : Research article

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Abstract

inactivated Newcastle disease virus (NDV) vaccines were prepared in
aluminium gel [A1(OH),] and oil emulsion (OE) adiuvants and compared
with a commercially produced oil edjuvant vaccine. The lentogenic
Hitchner B1 strailfigvas chosen as the best virus seed, giving an allantoic
fluid titre of 10 /ml. egg inlective dosesu and 7 log, haemagg|utinat-
ion titre. Virus inactivation was completed at 18 hours with final con-
centration ol formalin at ‘l:1UDO. Both oil emulsion and aluminium gel
vaccines were safe and immunogenic. The OE vaccine prepared from
local oils had a high viscosity and was unsuitable for field use.
Both OE and A1(OH), vaccines gave 80% protection for 6 months, with
geometric mean haemagglutination inhibition (HI) titers of 3.5 and 2.8
respectively with the A1 (OH), the protection percent was 93, B3 and
79 for the first, second and third month respectively. The protection
percent dropped to 70, 65 and 60 in the forth, filth and sixth month
respectively.

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