STUDIES ON TRICHINELLA SPIRALIS FOLIC ACID ANTAGONISTS IN THE TREATMENT OF EXPERIMENTAL TRICHINOSIS

Document Type : Research article

Author

Department of Parasitology, Faculty of Medicine, Tanta University, Tanta

Abstract

Rubidomycin is an antimitotic drug and used for the first time in the treatment of experimenal trichinosis in white rats. It is used in a dose of 2mg/rat/day. It gives 77%, 90%,96% and 98% reduction in the intensity of invasion in intestinal migrating non encapsulated and encapsulated phases of the disease respectively with little toxic effects especially in the early trichinosis.
Combined with thiabendazole it gives excellent results, almost 100% reduction in the intensity of infection during late trichinosis.