DIRECT AND TRANSPLACENTAL INDUCTION OF TUMOR IN RATS AFTER SINGIE EXPOSURE TO DIFLUBENZURON INSECTICIDE

Document Type : Research article

Authors

Dept. of Medicine, Faculty of Vet. Med., Zagazig University

Abstract

The oral LD50 of Diflubenzuron was determined in Agoza strain albino rats, survived animals were left and slaughtered after eleven months. Post mortem and histopatholo gical examination revealed the p < /strong>resence of squamous cell carcinoma in the stomach and polygonal cell carcinoma of the lungs. The offspring from mothers administered the LD50 dose at the 18th day of pregnancy developed hep < /strong>atocellular carcinoma which metastasis in their lungs. Detection, tissue distribution and evidence of transplac ental transmission of diflubenzuron were investigated by TLC, sp < /strong>ectrophotometric and Infra-red spectrscopic techniques.