EFFECT OF PROLONGED ADMINISTRATION OF ESTROGEN ON SOME BLOOD COAGULATION FACTORS IN RATS

The present study was planned to elucidate the influence of long term administration of estradiol benzoate on the blood coagulation parameters including activated partial thromboplastin time, plasma fibrinogen, prothrom bin, antihaemophilic factor, christmas factor and stuart factor.
The results revealed the following finding and conclusions: 1 - Activated partial thromboplastin time was significantly decreased post
estradiol benzoate administration in intact treated female rats after 21, 28 and 35 days; in ovariectomized treated rats after 14, 21, 28 and 35 days; in intact treated males after 35 days and in castrated
treated rats after 21, 28 and 35 days. 2- Plasma fibrinogen concentration was significantly increased post-estradiol
benzoate administration in intact treated females at all sampling days; in ovariectomized rats after 14, 21, 28 and 35 days; in intact treated males after 28 and 35 days and in castrated treated males at all sampl
ing days. 3- Plasma prothrombin (factor II) activity was significantly increased post
estrodiol benzoate administration in intact treated females after 21, 28 and 35 days; in ovariectomized treated rats after 14, 21, 28 and 35 days; in intact treated males after 14, 21, 28 and 35 days and in
castrated treated rats at all sampling days. 4- Plasma antihaemophilic factor (factor VIII) activity was significantly
increased post-estradiol benzoate administration in intact treated females after 14, 21, 28 and 35 days; in ovariectomized treated females after 21, 28 and 35 days; in intact treated males after 14, 21, 28 and 35
days and in castrated treated rats after 14, 21, 28 and 35 days. 5- Plasma Christmas factor (factor IX) activity was significantly increased
post-estradiol benzoate administration in intact treated females after 14, 21, 28 and 35 days; in ovariectomized treated females after 14, 21, 28 and 35 days; in intact and castrated treated males at all sampling days.
6- Plasma Stuart factor (factor X) activity was significantly increased
post-estradiol benzoate administration in intact treated females after 14, 21, 28 and 35 days; in ovariectomized treated rats at all sampling days; in intact treated males after 14, 21, 28 and 35 days and in castrat ed treated rats after 14, 21, 28 and 35 days.