DETERMINATION OF GENTAMICIN SULFATE IN PLASMA AND SYNOVIAL FLUID OF DONKEYS FOLLOWING ITS ADMINISTRATION

SELEIM, SAMIA M.; SELEIM, M.A.; YOUSSEF, H.A.; ABDALLA, S.

doi:10.21608/avmj.1992.187111

DETERMINATION OF GENTAMICIN SULFATE IN PLASMA AND SYNOVIAL FLUID OF DONKEYS FOLLOWING ITS ADMINISTRATION

Document Type : Research article

Authors

10.21608/avmj.1992.187111

Abstract

The concentrations of gentamicin sulfate in plasma and synovial fluid oc clinically healthy adult donkeys were measured periodically for 24 hours on twenty one donkeys after the intravenous and/or the intra articular administration of the drug. Synovial fluid samples were obtained via a catheter placed into the hock joint capsule and the blood was collec ted from the jugular vein. Gentamicin was assayed bacteriologically by the standard agar-cup diffusion method. Gentamicin sulfate concentration achieved in the synovial fluid after intra-articular administration with or without simultaneous intravenous injection, was greater than that achiev ed by intravenous injection alone. Although only traces of the drug was detected in the synovia after the intravenous administration of the drug, its concentration was markedly increased when the intravenous route was used in addition to the intra-articular injection in contract with the last route alone. The mean plasma concentration of gentamicin sulfate after intravenous administration was signiicantly greater than of all other routes of adminstration.