Intravenous administration of melatonin at doses of M 10 587 0.1-1 mg\kg BW in mature male rabbits decreased the best rectal temperature. The maximum effect, about 0.90 *°C, was reached with the highest dose (1 mg/kg) at 15 min after injection of melatonin. In addition, melatonin antagonized the prostaglandin Fza. (PGF 20)-induced hyp < /strong>erthermia. The hypothermic effect of melatonin in hyperthermic rabbits was more marked than that in animals with normal body temperature. Atropine, hydergine and prop < /strong>ranolol did not antagonize the hypothermic effect of melatonin. It can be concluded that melatonin decreases the body temp < /strong>erature in normal rabbits as well as in rabbits with hyp < /strong>erthermia. These results suggest that the hypothermic effect of melatonin is not mediated through the cholinergic or adrenergic recep < /strong>tors and may be due to its direct relaxant effect on the wall of the blood vessels. Also, melatonin may act centrally through inhibition of PG synthesis and release.
MOSTAFA, E. M., ELMILIGYDD, I. M., & ANWAR, M. (1994). EFFECT OF MELATONIN ON BODY TEMPERATURE IN THE RABBITS. Assiut Veterinary Medical Journal, 31.1(61), 345-355. doi: 10.21608/avmj.1994.185379
MLA
EMTETHAL M. MOSTAFA; IBTISAM M. ELMILIGYDD; M.M. ANWAR. "EFFECT OF MELATONIN ON BODY TEMPERATURE IN THE RABBITS". Assiut Veterinary Medical Journal, 31.1, 61, 1994, 345-355. doi: 10.21608/avmj.1994.185379
HARVARD
MOSTAFA, E. M., ELMILIGYDD, I. M., ANWAR, M. (1994). 'EFFECT OF MELATONIN ON BODY TEMPERATURE IN THE RABBITS', Assiut Veterinary Medical Journal, 31.1(61), pp. 345-355. doi: 10.21608/avmj.1994.185379
VANCOUVER
MOSTAFA, E. M., ELMILIGYDD, I. M., ANWAR, M. EFFECT OF MELATONIN ON BODY TEMPERATURE IN THE RABBITS. Assiut Veterinary Medical Journal, 1994; 31.1(61): 345-355. doi: 10.21608/avmj.1994.185379
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