UTERINE ACTIVITY AFTER THE CONTINUOUS INFUSION OF NIFEDIPINE IN THE OVARECTOMISED CAMEL (CAMELUS DROMEDARIUS)

Document Type : Research article

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Abstract

Three parous, non-pregnant camels were used in this study. Bilateral ovariectomy was performed in the three camels, and intrauterine and intraabdominal pressure changes were recorded using balloon-tipped catheters. Uterine contractions were induced and maintained in the ovariectomised camels by daily intramuscular injection of 5 mg estradiol benzoate throughout the experimental period. The frequency of uterine contractions varied from 6 to 9 per ten minutes, whereas the amplitude varied from 2 to 3 KPa. The continuous infusion of nifedipine at the dose rate of 0.012 mmol/kg/min for one hour succeeded in reducing the amplitude of uterine contractions in the three camels from a mean (USD) of 2.33 + 0.29 to 0.67 + 0.29 KP However, the frequency of uterine contractions was not affected.

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