EFFECT OF ALCOHOL ON THE POSTNATAL DEVELOPMENT OF CEREBELLAR CORTEX IN RAT II: ULTRASTRUCTURAL STUDY

SALEH, M.N.; SALEH, M.A.; DESOUKTY, M.A.; SAYED, SAADIA R.; SABER, ENTESAR A.

doi:10.21608/avmj.1995.184084

EFFECT OF ALCOHOL ON THE POSTNATAL DEVELOPMENT OF CEREBELLAR CORTEX IN RAT II: ULTRASTRUCTURAL STUDY

Document Type : Research article

Authors

10.21608/avmj.1995.184084

Abstract

In The present work, it was found that alcohol produced distinct changes in both Purkinje and granule cells during postnatal development. On the fifth day, the apical cones of the Purkinje cells were less developed and the cells showed an occasional somnatic spines but no somatic processes. At 21 days and adult stage these cells including their dendrites showed marked degenerative changes. The nuinber of basket cell axon synapses on Purkinje cell soma was reduced. There was also a reduction in the amount of basket fibers contributing to the pinceau around the intial seginent of the Purkinje cell axons. The granule cells showed a marked change starting from five days old. These cells decreased in size and lost most of the organelles. Their axons and dendrites as well as mossy fibers were also affected. Signs of glial activation and proliferation were present in the from of formation of myelin sheaths around the degenerated fibers.
EFFECT OF ALCOHOL ON THE POSTNATAL DEVELOPMENT OF CEREBELLAR CORTEX IN RAT
II: ULTRASTRUCTURAL STUDY

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