EFFECT OF ADMINISTRATION OF A-TOCOPHEROL, NIGELLA SATIVA SEEDS TOGETHER WITH DEEP FRIED FAT ON GLUTATHIONE DEPENDENT ENZYMES AND LIPID PEROXIDES IN RATS LIVER

Document Type : Research article

Authors

1 Dept. of Pharmacology, Fac. of Pharmacy, Alex. Univ.

2 Dept. of Biochemistry, Fac. of Vet. Med. Alex. Univ.

Abstract

In vivo studies were carried out to decide how vitamin E (dl. a-tocopherol acetate) and Nigella sativa seeds administrated orally combined with or without the deep fat frying (over heated oil) influence the glutathione dependent enzymes [(glutathione peroxidase (GP-ase), Glutathione reductase, (G-R-ase) and Glutathione transferase, (G-S-ase)), as well as reduced glutathione (GSH), Hydroxyl radical (OH) and lipid peroxidation (LP) of rat liver. It was found that, both vit. E and N.sativa seeds influence the action of deep fried fat but they are not able fully to prevent or eliminate its toxic effects.

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