INFLUENCE OF DMSA AND EDTA ON LEAD MOBILIZATION AND REDISTRIBUTION IN ALBINO RATS

Document Type : Research article

Authors

1 Dept. of Forensic Medicine and Toxicology, Fac. Vet. Med., Assiut Univ., Assiut Egypt

2 Dept. of Pathology & Clinical Pathology, Fac. Vet. Med., Assiut Univ.

Abstract

Seventy male albino rats were used. The rats were divided into three groups. The first, A and second B have been given 50 and 100 ppm lead, as lead acetate in drinking water respectively for three months. The third group, C was used as control. After that group (A and B) each was divided into four subgroups. These subgroups were given the recommended doses of either saline, mono calcium disodium ethylene diamine tetraacetic acid (CaNa EDTA), meso-2,3-dimercaptosuccinic acid (DMSA) or combination of CaNa EDTA and DMSA for one week. The animals were sacrificed, blood, liver, kidney, brain and bone were taken for determination of lead, copper and zinc. Serum creatinine, enzymatic activities (S-AST, serum glutamic oxalacetic transaminase; S ALT, serum glutamic pyruvic transaminase and S-ALP, serum alkaline phosphatase) and differential leucocytic count were estimated. The results indicated that: (I) The combination of CaNa2EDTA and DMSA was more efficient in reducing Pb concentration of liver, kidney and bone in comparison with each alone. However, the administration of DMSA alone was more effective than CaNa EDTA. (II) The brain Pb was depleted by DMSA more than by CaNa EDTA, while the combined chelation gave the same results as DMSA. (III) In the respect of differential leucocytic count, serum creatinine and the enzymatic activities, the DMSA gave the best results.

Keywords

Main Subjects

Assiut Veterinary Medical Journal
Volume 40.2, Issue 80
January 1999
Pages 242-259

Files

Share

How to cite

Statistics