EXPERIMENTAL STUDY FOR EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE AQUEOUS GARLIC EXTRACT IN TREATMENT OF ARTHRITIS IN RABBITS

A. AL-TALIBI, MOHAMMAD

doi:10.21608/avmj.2011.176922

EXPERIMENTAL STUDY FOR EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE AQUEOUS GARLIC EXTRACT IN TREATMENT OF ARTHRITIS IN RABBITS

Document Type : Research article

Author

MOHAMMAD A. AL-TALIBI

Dept. of Internal and Preventive Medicine, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

10.21608/avmj.2011.176922

Abstract

The study was conducted to evaluate the ability of Aqueous Garlic Extract (AGE) for inhibition the growth of Salmonella typhimurium as a probable cause of arthritis in rabbits in vitro and in vivo study. Results revealed that AGE (contain 201.2µg/ml allicin) have excellent antibacterial activity against this strain at ≥60% concentration, while the concentration ≥20% showed moderate activity, M oreover concentration of <20% show no effect in vitro. The in vivo study was explained the infectious dose of Salmonella typhimurium that induce arthritis in experimental animals was ≥ 1×10⁵ C.F.U/ml when injected intrarticularly. Garlic extract was administrated to treat experimental induced arthritis for 5 days by using different doses subcutaneously. It have been shown that a dose rate of 100mg/kg B.W S.C were more effective and have no adverse effects. Some bacteriology, serology and hematological tests were used as indicators to confirm infection and evaluation of treatment in rabbits.

References

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